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To evaluate the clinical and radiologic features of early rheumatoid arthritis (RA). A cross-sectional population-based study was conducted among 4818 subjects over 30 years old. A detailed questionnaire was used for the clinical evaluation and magnetic resonance imaging (MRI) of the hand and wrist was performed in 1891 participants. The proportions of RF positivity and the absence of erosive joint and extra-articular manifestations were significantly higher in subjects with early RA than in those with seronegative RA. The median levels of erythrocyte sedimentation rate, CRP, and rheumatoid factor (RF) were not significantly different in early and seronegative RA subjects. However, among the early RA subjects, the levels of erythrocyte sedimentation rate (p < 0.01), CRP (p < 0.01), and RF (p < 0.01) were significantly higher in the patients with MRI-positive and MRI-negative arthritis. Univariate logistic regression analysis showed that the absence of erosive arthritis [adjusted odds ratio (OR) = 0.76; 95% CI: 0.67-0.87], MRI-negative [adjusted OR = 0.40; 95% CI: 0.27-0.62] and absence of extra-articular manifestations [adjusted OR = 0.71; 95% CI: 0.58-0.86] were associated with a lower risk 0b46394aab